ingrid_STO said:PK/PD modeling for the pharmacology: understanding the pharmacokinetics helps optimize dosing.
Fair, and it stops being fair at the extremes. The middle of the range is well understood; the ends are where the honest answer is that nobody knows.
sarah.morrison said:The mechanism is more central than most summaries suggest.
Thank you — that is the clearest version of this I have read, and I have read a lot of them. Sending this to two other people who asked me the same thing last week.
ingrid_STO said:PK/PD modeling for the pharmacology: understanding the pharmacokinetics helps optimize dosing.
This is where I part company with the consensus forming above. Pushing back on the anecdote-stacking. Twenty people reporting the same thing is twenty samples from the same self-selected pool, not twenty independent confirmations.
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Browse GL BiochemOne concrete data point for the thread. Worth stating the units and the reference range whenever you post a number here. A large fraction of the apparent disagreement in these threads is two people using different units and both being right.
Moderator note: good thread. Keeping it here rather than moving it, because the question is general enough to be useful. Report rather than reply if it drifts again.