PharmacoVig_BOS said:There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.
Coming at PharmacoVig_BOS’s question from a different direction. It is worth asking what the claim would look like if it were false. If nothing would look different, it is not a claim about the world and no amount of discussion will settle it.
The figures, for anyone assembling their own picture. Practical: whatever you change, write down the date and the reason. In three months the reason is what you will have forgotten, and the reason is what makes the record worth having.
Correct me if the detail matters more than I have assumed.
Following on from PharmacoVig_BOS — and this may be the naive question:
What did you change at the same time, and can you separate the two now?
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Browse GL BiochemTrialTracker_MD said:Practical: whatever you change, write down the date and the reason.
Worth saying that the confident version of this is more useful to the person writing it than to the person reading it.
Closing the loop on my own question.
Update — tachyphylaxis to the gastric effect, persistence of the appetite effect. Two curves, and I had been watching the wrong one.