PharmD_Rodriguez said:The mental-health dimension is under-measured in the trial literature and the reports here are consistent enough to take seriously.
Agreed, and for anyone with an eating-disorder history this needs a clinician in the loop rather than a forum. The same drug can be therapeutic in binge-eating disorder and actively harmful in a restrictive disorder.
pat_auckland said:True, and anyone with reduced kidney function needs that target set by a clinician rather than a forum.
Thank you for spelling out the reasoning rather than just the conclusion. Sending this to two other people who asked me the same thing last week.
PharmD_Rodriguez said:The mental-health dimension is under-measured in the trial literature and the reports here are consistent enough to take seriously.
Pushing back on PharmD_Rodriguez here. I would be careful about how confidently the flatness reports get attributed. Rapid weight loss, a large deficit and disrupted sleep produce low mood on their own, and separating that from a drug effect is genuinely hard.
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