Adding the clinical framing, because it changes how the question reads. If two explanations both fit, the useful question is which one predicts something the other does not. That is answerable; arguing about which sounds more plausible is not.
PharmacoVig_BOS said:If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way.
There is a second half to this that has not been said yet. The mechanism and the magnitude are separate questions. Agreeing that something happens says nothing about whether it happens enough to act on.
One concrete data point for the thread. Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a trend.
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Shop Reference StandardsFollowing on from PharmacoVig_BOS — and this may be the naive question:
What would you measure differently if you were starting again?