EndoResFellow said:PK/PD modeling for the pharmacology: understanding the pharmacokinetics helps optimize dosing.
Correct, and worth adding that it is reversible. Nothing being described here is a one-way door, which changes how cautious it is reasonable to be.
LindaRN_retired said:The pharmacokinetics explain nearly every practical question asked here.
Genuinely useful, thank you. I had the facts and not the framework. Printing the relevant bit and taking it with me.
EndoResFellow said:PK/PD modeling for the pharmacology: understanding the pharmacokinetics helps optimize dosing.
I do not accept the framing. The question has been narrowed to the version that has a tidy answer, and the part that was dropped is the part the OP actually asked about.
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Browse GL BiochemOne concrete data point for the thread. Practical: whatever you change, write down the date and the reason. In three months the reason is what you will have forgotten, and the reason is what makes the record worth having.
Happy to go further on any of that.