DeniseRN_TPA said:If two explanations both fit, the useful question is which one predicts something the other does not.
That holds for the injectable. The oral formulation has different absorption behaviour and the dose numbers are not interchangeable, which is worth saying out loud because people quote them as if they were.
MariaRD said:The dose-response is real but shallow at the top.
That reframing is the part I needed.
DeniseRN_TPA said:If two explanations both fit, the useful question is which one predicts something the other does not.
Pushing back on DeniseRN_TPA here. The trial means are being read too generously in this thread. STEP populations were selected, supported, and titrated by protocol, and the real-world curves are consistently a few points worse. That difference is not noise, it is what happens when you remove the study infrastructure.
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Moderator note: leaving this open. It is being argued well and the disagreement is the useful part. Report rather than reply if it drifts again.