SarahChen_PharmD said:It is worth asking what the claim would look like if it were false.
Agreed, though "tolerable" needs defining. A dose you tolerate by eating almost nothing is not tolerated, it is being paid for somewhere else — usually in lean mass, sometimes in adherence three months later.
GraceAZ_72 said:Steady state is the thing most people miss.
That reframing is the part I needed. Printing the relevant bit and taking it with me.
SarahChen_PharmD said:It is worth asking what the claim would look like if it were false.
I read this differently from SarahChen_PharmD, on substance rather than tone. The trial means are being read too generously in this thread. STEP populations were selected, supported, and titrated by protocol, and the real-world curves are consistently a few points worse. That difference is not noise, it is what happens when you remove the study infrastructure.
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