Dr.PulmRoch said:FLOW is the relevant trial and it reported a meaningful reduction in kidney-disease progression and related death in people with type 2 diabetes and…
That holds for the injectable. The oral formulation has different absorption behaviour and the dose numbers are not interchangeable, which is worth saying out loud because people quote them as if they were.
KristenIndy said:Steady state is the thing most people miss.
Bookmarking. The distinction being drawn above is the one nobody else makes.
Dr.PulmRoch said:FLOW is the relevant trial and it reported a meaningful reduction in kidney-disease progression and related death in people with type 2 diabetes and…
I will push back on the "any working dose is fine" framing. The maintenance evidence sits overwhelmingly at the top studied dose, and the extension data shows regain tracking dose reduction rather than tracking stopping. Holding low is reasonable; pretending it is evidentially equivalent is not.
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View ResultsAdding the numbers, since they settle part of this. Worth knowing that eGFR estimates depend on creatinine, and creatinine depends on muscle mass. Losing muscle raises eGFR artificially, which flatters the number while the kidney is unchanged.
That is the short version; the long version is somebody else's post.