Dr.RenalNash said:The OASIS programme put 50mg oral in the same territory as 2.4mg injectable — around 15% mean weight loss — but it needed a dose 20 times larger to…
I do not accept that the fasting window is a minor inconvenience. Adherence data on daily orals with timing requirements is consistently worse than weekly injections, and a drug you take imperfectly is a lower dose than the one on the box.
The figures, for anyone assembling their own picture. Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a trend.
JennaRN said:I do not accept that the fasting window is a minor inconvenience.
Coming at JennaRN’s question from a different direction. If two explanations both fit, the useful question is which one predicts something the other does not. That is answerable; arguing about which sounds more plausible is not.
I would rather be corrected than agreed with, if it comes to it.
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View ResultsOne thing that is still open after hans_munich’s answer:
How much of the oral variability is the SNAC absorption window and how much is dose, because the two get conflated constantly?
Closing the loop on my own question.
Update — I went back to the injectable. Not because the tablet did not work, but because the fasting window and my mornings were never going to agree.