Dr.AddMedPHL said:Anti-inflammatory mechanisms of GLP-1 agonists and cardiovascular risk: beyond weight loss, GLP-1R activation directly suppresses NF-κB signaling,…
This answered a question I did not know how to ask. Taking it to my next appointment.
From the other side of the consultation, briefly.
6 month update on cardiovascular risk: down 38 lbs, off blood pressure meds, A1C normalized. Genuinely life-changing.
sophie_paris said:6 month update on cardiovascular risk: down 38 lbs, off blood pressure meds, A1C normalized.
This matches mine closely enough to be worth saying so out loud.
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Browse GL Biochemsophie_paris said:6 month update on cardiovascular risk: down 38 lbs, off blood pressure meds, A1C normalized.
There is a second half to this that has not been said yet. The dose-response is real but shallow at the top. Across STEP 1 and STEP 4 the gap between 1.7mg and 2.4mg is a couple of percentage points of body weight on average, and the average is carrying a wide spread — plenty of people at 1.7mg sit above the 2.4mg mean. If a dose is working and tolerable, "working" is the relevant variable, not "maximal".
sophie_paris said:6 month update on cardiovascular risk: down 38 lbs, off blood pressure meds, A1C normalized.
I'm 58 years old and want to share my perspective on cardiovascular risk as an older member of this community.
My doctor was initially hesitant because of my age, but the SELECT trial included patients up to 72 and showed consistent benefit across age groups. We started at the lowest dose with closer monitoring.
16 months later: down 63 lbs, off metoprolol, A1C from 8.6% to 5.4%. My cardiologist is thrilled. cardiovascular risk is absolutely relevant for older adults — don't let anyone tell you otherwise.