InsuranceTom said:The trials generally allowed a step to be held or reduced and then retried, and people who did that mostly arrived at the same place a few weeks…
I disagree that the ladder is purely tolerability. The maintenance and regain data cluster at the top doses, so a ladder abandoned halfway leaves you outside the evidence base for the part that matters most — keeping it off.
Dr.PathRoch said:Four dose steps in, holding each one the full four weeks, and I am trying to work out whether the interval is a pharmacological requirement or a…
PSA for titration users considering the 0.25mg starting dose: this dose is NOT intended for weight loss. It's a titration dose to let your body adjust. Don't be discouraged if you don't lose much in the first month.
The therapeutic dose for weight management starts at 1.7mg (semaglutide) or 5mg (tirzepatide). Be patient with the ramp-up.
HPLC_Greg said:I disagree that the ladder is purely tolerability.
There is a second half to this that has not been said yet. The distinction that resolves most of these threads is between what is true on average and what is true for one person. Both are real; they answer different questions and get quoted as if they were the same one.
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Shop Reference StandardsOne thing that is still open after emma_london’s answer:
Why the interval is four weeks rather than two, and whether a slower ladder gets to the same place?
Closing the loop on my own question.
Closing this out: I held the step for six weeks rather than four and it settled without a dose change. The interval was the answer, not the dose.