May 16, 2026 at 6:40 PM#1
Today marks exactly 1 year on brand Mounjaro. I've been tracking EVERYTHING in a spreadsheet because I'm that person. Here's my complete journey for anyone starting out or considering tirz.
Stats: 38F, 5'7", starting weight 267 lbs
THE FULL TIMELINE:
Weeks 1-4 (2.5mg)
- Weight: 267 → 260 (-7 lbs, mostly water)
- Side effects: mild nausea days 1-3 of each injection, slight constipation, sulfur burps (THE WORST)
- Appetite: barely changed
- Energy: slightly lower
- Mood: anxious about side effects, otherwise normal
Weeks 5-8 (5mg)
- Weight: 260 → 249 (-11 lbs)
- Side effects: nausea returned first week of titration then faded, constipation worsened (started Miralax daily), sulfur burps continued, injection site itching
- Appetite: definitely reduced, first time I left food on my plate involuntarily
- Energy: normalizing
- Mood: excited about weight loss, slight emotional flatness
Weeks 9-12 (7.5mg)
- Weight: 249 → 237 (-12 lbs)
- Side effects: sulfur burps FINALLY stopped, constipation manageable with Miralax + fiber, mild hair shedding started (telogen effluvium), period became irregular
- Appetite: significantly reduced, food noise mostly gone
- Energy: good, stable throughout day
- Mood: great, confidence building
41 11Dr.PathRoch, mona_PHX, andrew_nyc and 38 others
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May 16, 2026 at 7:08 PM#2
Weeks 13-16 (10mg)
- Weight: 237 → 226 (-11 lbs)
- Side effects: hair shedding peaked (terrifying but expected — it's from the weight loss, not the drug), constipation improving, one episode of reactive hypoglycemia after eating plain rice
- Appetite: could easily skip meals, had to set reminders to eat
- Energy: excellent
- Mood: best it's been in years
Weeks 17-20 (10mg — stayed here)
- Weight: 226 → 220 (-6 lbs, slowing down)
- Side effects: hair shedding slowing, constipation mostly resolved (still take Miralax 3x/week), skin getting loose on arms and inner thighs
- Appetite: stable, eating 1200-1500 cal without effort
- Energy: excellent
- Mood: very stable
Weeks 21-32 (12.5mg)
- Weight: 220 → 205 (-15 lbs over 12 weeks)
- Side effects: new side effect — dry eyes (weird, looked it up, possibly related to reduced inflammation or lacrimal gland changes), hair shedding stopped, skin looseness more noticeable
- Appetite: very controlled
- Energy: high
- Mood: occasional emotional days but overall positive
- Notable: first blood panel since starting — all metabolic markers dramatically improved (see table below)
40 10raj_cambridge, ingrid_STO, pete_nash and 37 others
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May 16, 2026 at 7:36 PM#3
Blood panel at week 28:
| Marker | Before tirz | Week 28 | Change |
|--------|------------|---------|--------|
| A1C | 6.0% | 5.2% | -0.8% |
| Fasting glucose | 108 | 84 | -22% |
| Total cholesterol | 234 | 178 | -24% |
| LDL | 148 | 102 | -31% |
| HDL | 42 | 58 | +38% |
| Triglycerides | 198 | 94 | -53% |
| ALT | 52 | 24 | -54% |
| hs-CRP | 8.4 | 1.2 | -86% |
| Blood pressure | 138/88 | 118/74 | normalized |
My doctor literally said "your labs look like a different person." The hs-CRP drop is insane — 86% reduction in systemic inflammation.
Weeks 33-44 (12.5mg continued)
- Weight: 205 → 194 (-11 lbs over 12 weeks, definitely slower)
- Side effects: dry eyes persisted (using artificial tears), mild fatigue some weeks (possibly related to caloric intake being too low — increased to 1500-1600/day and it resolved), loose skin becoming my main cosmetic concern
- Appetite: stable, can eat normally but satisfied with less
- Energy: good when eating enough
- Mood: stable
Weeks 45-52 (12.5mg — present)
- Weight: 194 → 189 (-5 lbs, approaching plateau)
- Side effects: mostly resolved, just dry eyes and loose skin
- Appetite: finding a new normal, can enjoy meals again without overeating
- Energy: great
- Mood: best mental health of my adult life honestly
Last edited: May 17, 2026 at 12:36 AM
39 9ingrid_STO, pete_nash, hank_denver and 36 others
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PeptideDetective — Independent Peptide Analytics
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View ResultsMay 16, 2026 at 8:04 PM#4
SUMMARY:
| Metric | Start | 1 year | Change |
|--------|-------|--------|--------|
| Weight | 267 lbs | 189 lbs | -78 lbs (-29.2%) |
| BMI | 41.8 | 29.6 | -12.2 |
| Waist | 44" | 33" | -11" |
| Clothing size | 22 | 12 | -10 sizes |
| A1C | 6.0% | 5.2% | -0.8% |
| Blood pressure | 138/88 | 118/74 | normalized |
Side effects I experienced (sorted by duration):
1. Sulfur burps — weeks 1-10 (resolved)
2. Nausea — weeks 1-6 intermittent (resolved)
3. Constipation — weeks 3-20 (mostly resolved, occasional)
4. Hair shedding — weeks 10-24 (resolved, hair growing back)
5. Irregular periods — weeks 8-28 (resolved, regular again)
6. Injection site reactions — weeks 5-16 (resolved)
7. Reactive hypoglycemia — 3 episodes total (learned to avoid naked carbs)
8. Dry eyes — week 22-present (ongoing, manageable)
9. Loose skin — week 18-present (ongoing, considering treatment options)
10. Fatigue — intermittent, correlated with undereating
What I'd tell someone starting:
- Trust the titration schedule
- Protein, protein, protein (I aim for 130g/day)
- Don't panic about hair loss — it comes back
- Miralax is your friend
- Take progress photos monthly — the mirror lies, photos don't
- Get bloodwork every 3-4 months
- This drug changed my life. Not an exaggeration. ❤️
38 8pete_nash, hank_denver, carlos_SATX and 35 others
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May 16, 2026 at 10:36 PM#5
This is the most detailed tirz timeline I've ever read. Saving this entire thread. Thank you for being so thorough.
Questions:
1. The sulfur burps — how bad were they really? I keep hearing about them and I'm dreading it
2. Did you exercise throughout? What kind?
3. Would you do anything differently?
Last edited: May 17, 2026 at 4:36 AM
37 7hyun_seoul, jim_asheville, matt_MKE and 34 others
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